Interaction of a partial agonistic allosteric/orthosteric hybrid compound with an allosteric antagonist on muscarinic M2 receptors

被引:0
|
作者
Kellershohn, K
Muth, M
De Amici, M
Holzgrabe, U
Mohr, K
机构
[1] Univ Bonn, Inst Pharm, D-53121 Bonn, Germany
[2] Univ Wurzburg, Inst Pharm & Food Chem, D-97074 Wurzburg, Germany
[3] Univ Milan, Inst Med & Toxicol Chem, I-20131 Milan, Italy
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
87
引用
收藏
页码:34 / 34
页数:1
相关论文
共 50 条
  • [21] Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist
    Maren Großmüller
    Johannes Antony
    Christian Tränkle
    Ulrike Holzgrabe
    Klaus Mohr
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2006, 372 : 267 - 276
  • [22] Allosteric site in M2 acetylcholine receptors:: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist
    Grossmüller, M
    Antony, J
    Tränkle, C
    Holzgrabe, U
    Mohr, K
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2006, 372 (04) : 267 - 276
  • [23] The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria
    Lanzafame, A
    Christopoulos, A
    Mitchelson, F
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 416 (03) : 235 - 244
  • [24] Allosteric regulation of the binding of [H-3]acetylcholine to m2 muscarinic receptors
    Gnagey, A
    Ellis, J
    BIOCHEMICAL PHARMACOLOGY, 1996, 52 (11) : 1767 - 1775
  • [25] Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors
    May, Lauren T.
    Avlani, Vimesh A.
    Langmead, Christopher J.
    Herdon, Hugh J.
    Wood, Martyn D.
    Sexton, Patrick M.
    Christopoulos, Arthur
    MOLECULAR PHARMACOLOGY, 2007, 72 (02) : 463 - 476
  • [26] Investigating the structural determinants underlying allosteric agonism at M2 muscarinic acetylcholine receptors
    Gregory, Karen Joan
    May, Lauren T.
    Sexton, Patrick M.
    Christopoulos, Arthur
    FASEB JOURNAL, 2007, 21 (06): : A789 - A789
  • [27] Discovery and characterization of orthosteric and allosteric muscarinic M2 acetylcholine receptor ligands by affinity selection-mass spectrometry
    Whitehurst, CE
    Nazef, N
    Annis, DA
    Hou, YM
    Murphy, DM
    Spacciapoli, P
    Yao, ZP
    Ziebell, MR
    Cheng, CC
    Shipps, GW
    Flesch, JS
    Lau, D
    Nash, HM
    JOURNAL OF BIOMOLECULAR SCREENING, 2006, 11 (02) : 194 - 207
  • [28] Structure/activity relationships of M2 muscarinic allosteric modulators
    Mohr, K
    Tränkle, C
    Holzgrabe, U
    RECEPTORS & CHANNELS, 2003, 9 (04): : 229 - 240
  • [29] Exploration of the Orthosteric/Allosteric Interface in Human M1 Muscarinic Receptors by Bitopic Fluorescent Ligands
    Daval, Sandrine B.
    Kellenberger, Esther
    Bonnet, Dominique
    Utard, Valerie
    Galzi, Jean-Luc
    Ilien, Brigitte
    MOLECULAR PHARMACOLOGY, 2013, 84 (01) : 71 - 85
  • [30] A novel alcuronium-derived allosteric enhancer of ligand binding to muscarinic M2 receptors
    Tränkle, C
    Holzgrabe, U
    Mohr, K
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R85 - R85