Poly(Caprolactone)-Poly(N-Isopropyl Acrylamide)-Fe3O4Magnetic Nanofibrous Structure with Stimuli Responsive Drug Release

Poly(caprolactone; PCL)-poly(N-isopropylacrylamie; PNIPAAm)-Fe(3)O(4)fiber, that can be magnetically actuated, is reported. Here, a structure is engineered that can be utilized as a smart carrier for the release of chemotherapeutic drug via magneto-thermal activation, with the aid of magnetic nanoparticles (MNPs). The magnetic measurement of the fibers revealed saturation magnetization values within the range of 1.2-2.2 emu g(-1). The magnetic PCL-PNIPAAm-Fe(3)O(4)scaffold shows a specific loss power value of 4.19 W g(-1)at 20 wt% MNPs. A temperature increase of 40 degrees C led to a 600% swelling after only 3 h. Doxorubicin (DOX) as a model drug, demonstrates a controllable drug release profile. 39% +/- 0.92 of the total drug loaded is released after 96 h at 37 degrees C, while 25% drug release in 3 h at 40 degrees C is detected. Cytotoxicity results show no significant difference in cell attachment efficiency between the MNP-loaded fibers and control while the DOX-loaded fibers effectively inhibited cell proliferation at 24 h matching the drug release profile. The noncytotoxic effect, coupled with the magneto-thermal property and controlled drug release, renders excellent potential for these fibers to be used as a smart drug-release agent for localized cancer therapy.