Targeted therapies and hypoxia imaging

被引:0
|
作者
Ali, R. [1 ]
Graves, E. E. [1 ]
机构
[1] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA
来源
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2013年 / 57卷 / 03期
关键词
Molecular imaging; Cell hypoxia; Antineoplastic agents; POSITRON-EMISSION-TOMOGRAPHY; NECK-CANCER; TUMOR HYPOXIA; ADVANCED HEAD; QUANTITATIVE ASSESSMENT; ACTIVATED PRODRUG; LUNG-CANCER; TIRAPAZAMINE; CELL; PET;
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Hypoxia-specific cytotoxins have long exhibited considerable promise for treating hypoxic tumors, however recent negative results in large scale clinical trials have highlighted the importance of selecting patients who are most likely to respond using hypoxia imaging methods. This review looks at the available hypoxia-specific cytotoxins and describes how existing hypoxia imaging methods can be best used to predict which tumors will respond. It then surveys prior studies which combine hypoxia-selective cytotoxin treatment with hypoxia imaging, and finally concludes with a discussion of what lessons can be learnt from previous experiences in order to improve the use of these cytotoxic agents in future clinical evaluations.
引用
收藏
页码:283 / 295
页数:13
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