Vasoconstriction induced by salivary gland extracts from ixodid ticks

被引：6
|
作者：
Pekarikova, Danica [1 ]
Rajska, Petra [1 ]
Kazimirova, Maria [1 ]
Pechanova, Olga [2 ]
Takac, Peter [1 ]
Nuttall, Patricia A. [3 ,4 ]
机构：
[1] Slovak Acad Sci, Inst Zool, Bratislava 84506, Slovakia
[2] Slovak Acad Sci, Inst Normal & Pathol Physiol, Bratislava 81371, Slovakia
[3] NERC, Ctr Ecol & Hydrol, Wallingford, Oxon, England
[4] Univ Oxford, Dept Zool, Oxford OX1 2JD, England
来源：
INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2015年 / 45卷 / 14期
基金：
英国自然环境研究理事会;
关键词：
Tick; Salivary glands; Vasoactivity; Vasoconstriction; Vasodilation; Rat femoral artery; PROSTAGLANDINS;
D O I：
10.1016/j.ijpara.2015.08.006
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
In their quest for blood, most haematophagous parasites secrete vasodilators in their saliva to counter the host haemostatic response of vasoconstriction. Surprisingly, salivary gland extracts from adult female Dermacentor reticulatus and Rhipicephalus appendiculatus ticks induced constriction in a rat femoral artery model; males induced vasoconstriction or vasodilation depending on the time of feeding. Based on comparative HPLC fractionation, the active compounds inducing vasoconstriction do not appear to be prostaglandins (which ticks normally use as vasodilators). Vasoconstriction may be unique to ixodid ticks, helping them control blood flow during their prolonged blood-feeding of up to 10 days or more. (C) 2015 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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页码：879 / 883
页数：5
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