Discovering translational biomarkers in neurodevelopmental disorders

被引：42

作者：

Sahin, Mustafa ^{[1
,2
]}

Jones, Stephanie R. ^{[3
,4
,5
]}

Sweeney, John A. ^{[6
]}

Berry-Kravis, Elizabeth ^{[7
]}

Connors, Barry W. ^{[3
,4
]}

Ewen, Joshua B. ^{[8
,9
]}

Hartman, Adam L. ^{[10
]}

Levin, April R. ^{[1
,2
]}

Potter, William Z. ^{[11
]}

Mamounas, Laura A. ^{[10
]}

机构：

[1] Boston Childrens Hosp, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Brown Univ, Providence, RI 02912 USA

[4] Alpert Med Sch, Providence, RI USA

[5] Providence VA Med Ctr, Ctr Neurorestorat & Neurotechnol, Providence, RI USA

[6] Univ Cincinnati, Cincinnati, OH USA

[7] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[8] Kennedy Krieger Inst, Baltimore, MD USA

[9] Johns Hopkins Univ, Baltimore, MD USA

[10] NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD USA

[11] NIMH, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2019年 / 18卷 / 04期

关键词：

D O I：

10.1038/d41573-018-00010-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Investment in drug development for neurodevelopmental disorders has suffered from recent failures in clinical trials that were based on promising preclinical findings. Here, we discuss development and validation of translational biomarkers of neurodevelopmental disorders that can enable more informative clinical experiments and translational success in these diseases.

引用

页码：235 / 236

页数：2

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