Animal models of airway inflammation and airway smooth muscle remodelling in asthma

被引：25

作者：

Allen, Judith E. ^{[2
]}

Bischof, Robert J. ^{[1
]}

Chang, Herng-Yu Sucie ^{[3
]}

Hirota, Jeremy A. ^{[5
]}

Hirst, Stuart J. ^{[4
]}

Inman, Mark D. ^{[5
]}

Mitzner, Wayne ^{[3
]}

Sutherland, Tara E. ^{[2
]}

机构：

[1] Monash Univ, Sch Biomed Sci, Dept Physiol, Biotechnol Res Labs, Clayton, Vic 3800, Australia

[2] Univ Edinburgh, Sch Biol Sci, Inst Infect & Immunol, Ashworth Lab, Edinburgh, Midlothian, Scotland

[3] Johns Hopkins Univ, Baltimore, MD USA

[4] Monash Univ, Dept Physiol, Sch Biomed Sci, Clayton, Vic 3168, Australia

[5] Firestone Inst Resp Hlth, Dept Med, Hamilton, ON, Canada

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2009年 / 22卷 / 05期

基金：

英国医学研究理事会; 美国国家卫生研究院; 加拿大健康研究院;

关键词：

Animal model; Asthma; Airway inflammation; Airway remodelling; Airway smooth muscle; ALTERNATIVELY ACTIVATED MACROPHAGES; HOUSE-DUST MITE; ESTROGEN REPLACEMENT THERAPY; INDUCED MITOGENIC FACTOR; CD4(+) T-CELLS; ALLERGIC LUNG INFLAMMATION; SENSITIZED GUINEA-PIGS; PULMONARY-DISEASE COPD; BROWN-NORWAY RATS; MURINE MODEL;

D O I：

10.1016/j.pupt.2009.04.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Asthma is a complex disease that involves chronic inflammation and subsequent decline in airway function. The widespread use of animal models has greatly contributed to our understanding of the cellular and molecular pathways underlying human allergic asthma. Animal models of allergic asthma include smaller animal models which offer 'ease of use' and availability of reagents, and larger animal models that may be used to address aspects of allergic airways disease not possible in humans or smaller animal models. This review examines the application and suitability of various animal models for studying mechanisms of airway inflammation and tissue remodelling in allergic asthma, with a specific focus on airway smooth muscle. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：455 / 465

页数：11

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