Reductive cleavage of N-O bonds using samarium(II) iodide in a traceless release strategy for solid-phase synthesis

被引：32
|
作者：
Myers, RM [1 ]
Langston, SP [1 ]
Conway, SP [1 ]
Abell, C [1 ]
机构：
[1] Univ Cambridge, Chem Labs, Cambridge CB2 1EW, England
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 10期
关键词：
D O I：
10.1021/ol0055162
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] (i) p-anisoyl chloride, diisopropylethylamine, dichloromethane, 25 degrees C, 16 h. (ii) DBU, 4-bromobenzyl bromide, toluene, 25 degrees C, 48 h. (iii) SmI2/ THF, 25 degrees C, 3 h. A strategy for malting amides and ureas using a polymer-supported hydroxylamine resin as a traceless linker is described. The cleavage of the linker by samarium(II) iodide is reported for the first time.
引用
收藏
页码：1349 / 1352
页数：4
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