N-terminal of the prohormone brain natriuretic peptide is a predictor of hemodynamic instability in valve disease

被引：8
|
作者：
Duchnowski, Piotr [1 ]
Hryniewiecki, Tomasz [1 ]
Kusmierczyk, Mariusz [2 ]
Szymanski, Piotr [1 ]
机构：
[1] Inst Cardiol, Dept Acquired Cardiac Defects, Warsaw, Poland
[2] Inst Cardiol, Dept Cardiosurg & Transplantol, Warsaw, Poland
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 05期
关键词：
biomarkers; extracorporeal intraaortic balloon pump; heart failure; heart valve surgery; membrane oxygenation; NT-proBNP; perioperative strategy; postoperative hemodynamic instability; support with catecholamines; valve disease; SURGERY; BNP;
D O I：
10.2217/bmm-2019-0002
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: The usefulness of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) as a predictor of perioperative hemodynamic instability is not fully elucidated. Methods: This prospective study was conducted on a group of 455 patients undergoing elective heart valve surgery. The primary endpoint at the 30-day follow-up was postoperative hemodynamic instability. The secondary end point was death from all causes in patients with postoperative hemodynamic instability. Results: The postoperative hemodynamic instability occurred in 85 patients. At multivariate analysis NT-proBNP, New York Heart Association classes and glomerular filtration rate remained independent predictors of the primary endpoint. Age and NT-proBNP were associated with an increased risk of death. Conclusion: The preoperative NT-proBNP can be used to predict a postoperative hemodynamic instability as well as death in the group of patients with postoperative hemodynamic instability.
引用
收藏
页码：353 / 358
页数：6
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