Synergistic effect of radon in blood cells of smokers - An in vitro study

被引：15

作者：

Meenakshi, C. ^{[1
]}

Mohankumar, Mary N. ^{[1
]}

机构：

[1] Indira Gandhi Ctr Atom Res, Radiol Safety Div, Kalpakkam 603102, Tamil Nadu, India

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2013年 / 757卷 / 01期

关键词：

DNA damage; Radon; Smokers; Synergistic effect; Chromosome aberrations; CHROMOSOME-ABERRATION FREQUENCIES; URANIUM MINERS; DNA-DAMAGE; EXPOSURE; LYMPHOCYTES; REPAIR; RISK; CANCER; BIOMARKERS; INDUCTION;

D O I：

10.1016/j.mrgentox.2013.06.018

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Epidemiological studies indicate that the risk of lung cancer among smokers increases with exposure to residential radon. The present study aimed to investigate the synergetic effect between smoking and radon. Blood samples from smokers and non-smokers were exposed to different concentrations of radon ranging from 0 to 189 MBq/m(3) corresponding to doses ranging from 0.2 to 15.2 mGy. Chromosome aberrations in first division metaphase preparations were scored. The frequency of dicentrics in radon-exposed smoker cells was found to be higher than non-smokers by factor of 3.8. The present study is the first of its kind to investigate the interaction of radon and smoking sans confounding factors, as smoker cells were exposed in vitro to radon. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：79 / 82

页数：4

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