Larvicidal and structural studies of some triphenyl- and tricyclohexyltin para-substituted benzoates

Several new triphenyl- and tricyclohexyltin para-substituted benzoates were synthesized. Their structures were characterized by IR and Mossbauer spectroscopies. The structures were determined to be four-coordinated monomers. Larvicidal activities of the new compounds as well as other benzoates were evaluated against the 2nd larval instar of the Anopheles stephensi and Aedes aegypti mosquitoes. Results from the screening studies indicated that the triphenyltin benzoates were more toxic towards the Ae. aegypti larvae. A quantitative-structure activity relationship was also developed for the Art. stephensi larvae. (c) 2005 Elsevier B.V. All rights reserved.