A Convenient Regioselective Synthesis of Novel 1,4-Phenylenemethylene-6,6′-bis-([1,2,4-triazolo]-[4,3-b][1,2,4]-triazin-7(1H)-ones)

被引：2

作者：

Hassaneen, Hamdi M. ^{[1
]}

Saleh, Fatma M. ^{[1
]}

Mohammed, Yasmin Sh. ^{[2
]}

Awad, Enas M. ^{[3
]}

机构：

[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt

[2] Natl Org Drug Control & Res, Giza, Egypt

[3] Natl Res Ctr, Res Div Pharmaceut & Drug Ind, Dept Nat & Microbial Prod, Giza, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 06期

关键词：

ANTIBACTERIAL AGENTS; ACID-DERIVATIVES; 1,2,4-TRIAZINE; HALIDES; HETEROCYCLES; SYSTEMS; ROUTES;

D O I：

10.1002/jhet.2910

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The target compounds 6,6'-(1,4-phenylenedimethylene)-bis(3-thioxo-1,2,4-triazin-5(1H)-one) 4,5 were prepared from reaction of oxazolone 1 with thiosemicarbazide and 4-phenylthiosemicarbazide, in potassium hydroxide solution, respectively. Reaction of 4 with hydrazonoyl halides 6 afforded triazolotriazine derivatives 7. Also, 5 reacted with 6 to give the corresponding substitution products 8. Antimicrobial and antitumor activities for some compounds were studied.

引用

页码：3015 / 3022

页数：8

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