Analysis of urinary andrographolides and antioxidant status after oral administration of Andrographis paniculata leaf extract in rats

被引：28
|
作者：
Akowuah, G. A. [1 ]
Zhari, I. [2 ]
Mariam, A. [2 ]
机构：
[1] Univ Coll Sedaya Int, Sch Pharm, Kuala Lumpur 56000, Malaysia
[2] Univ Sains Malaysia, Sch Pharmaceut Sci, Minden 11800, Penang, Malaysia
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2008年 / 46卷 / 12期
关键词：
Andrographolides; Andrographis paniculata; Rats; Urine; Antioxidant status;
D O I：
10.1016/j.fct.2008.09.008
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
A simple high-performance liquid chromatography (HPLC) method was developed to determine the content of andrographolide (AP) and 14-deoxy-11, 12-dideoxyandrographolide (DIAP) in a pooled urine of rat obtained within 24 h after an oral dose of Andrographis paniculata leaf extract at 1 g/kg body weight. Cumulative urinary excretion of AP and DIAP in 24 h after oral administration of the extract was 0.88% and 1.61% of oral dose administered, respectively. The extract showed significant reduction (p < 0.05) of MDA levels and elevation of total antioxidant status in rat urine samples collected in 24 after oral administration. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3616 / 3620
页数：5
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