Analysis of urinary andrographolides and antioxidant status after oral administration of Andrographis paniculata leaf extract in rats

被引：28
|
作者：
Akowuah, G. A. [1 ]
Zhari, I. [2 ]
Mariam, A. [2 ]
机构：
[1] Univ Coll Sedaya Int, Sch Pharm, Kuala Lumpur 56000, Malaysia
[2] Univ Sains Malaysia, Sch Pharmaceut Sci, Minden 11800, Penang, Malaysia
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2008年 / 46卷 / 12期
关键词：
Andrographolides; Andrographis paniculata; Rats; Urine; Antioxidant status;
D O I：
10.1016/j.fct.2008.09.008
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
A simple high-performance liquid chromatography (HPLC) method was developed to determine the content of andrographolide (AP) and 14-deoxy-11, 12-dideoxyandrographolide (DIAP) in a pooled urine of rat obtained within 24 h after an oral dose of Andrographis paniculata leaf extract at 1 g/kg body weight. Cumulative urinary excretion of AP and DIAP in 24 h after oral administration of the extract was 0.88% and 1.61% of oral dose administered, respectively. The extract showed significant reduction (p < 0.05) of MDA levels and elevation of total antioxidant status in rat urine samples collected in 24 after oral administration. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3616 / 3620
页数：5
相关论文
共 50 条
  • [1] Effect of Andrographis paniculata leaf extract on wound healing in rats
    Al-Bayaty, Fouad Hussain
    Abdulla, Mahmood Ameen
    Abu Hassan, Mohamed Ibrahim
    Ali, Hapipah Mohd
    NATURAL PRODUCT RESEARCH, 2012, 26 (05) : 423 - 429
  • [2] Erythropoietic Evaluation of Andrographis paniculata Leaf Extract in Wistar Rats
    Nosiri, Chidi
    Ama, Godwin
    Atasie, Okechukwu
    Oguike, Victor
    Omekara, Amaka
    Aguwamba, Chinedu
    Nwaogwugwu, Caleb
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (03) : S82 - S82
  • [3] Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats
    Balap, Aishwarya
    Atre, Bhagyashri
    Lohidasan, Sathiyanarayanan
    Sinnathambi, Arulmozhi
    Mahadik, Kakasaheb
    JOURNAL OF ETHNOPHARMACOLOGY, 2016, 183 : 9 - 17
  • [4] Antioxidant and α-glucosidace inhibitory activities of the Andrographis paniculata Nees. ultrasonic leaf extract
    Utami, Andita
    Irawan, Candra
    Sukiman, Maman
    Ismail
    Putri, Imalia Dwi
    Pratama, Andrean Nur
    Septian, Wira Aditia
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2024, 37 (04) : 769 - 776
  • [5] In vitro antioxidant and anti-diabetic analysis of Andrographis echioides and Andrographis paniculata ethanol extract
    Reddy, Chevuru Sai Shreya
    Ramalingam, Gayatri Devi
    Selvaraj, J.
    Priya, Jothi
    BIOINFORMATION, 2022, 18 (04) : 337 - 342
  • [6] Andrographis paniculata Leaf Extract Prevents Thioacetamide-Induced Liver Cirrhosis in Rats
    Bardi, Daleya Abdulaziz
    Halabi, Mohammed Farouq
    Hassandarvish, Pouya
    Rouhollahi, Elham
    Paydar, Mohammadjavad
    Moghadamtousi, Soheil Zorofchian
    Al-Wajeeh, Nahla Saeed
    Ablat, Abdulwali
    Abdullah, Nor Azizan
    Abdulla, Mahmood Ameen
    PLOS ONE, 2014, 9 (10):
  • [7] Phytochemical analysis of Andrographis paniculata and Orthosiphon stamineus leaf extracts for their antibacterial and antioxidant potential
    Malahubban, M.
    Alimon, A. R.
    Sazili, A. Q.
    Fakurazi, S.
    Zakry, F. A.
    TROPICAL BIOMEDICINE, 2013, 30 (03) : 467 - 480
  • [8] Acute oral toxicity evaluation of Andrographis paniculata-standardized first true leaf ethanolic extract
    Worasuttayangkurn, Luksamee
    Nakareangrit, Watanyoo
    Kwangjai, Jackapun
    Sritangos, Pishyaporn
    Pholphana, Nanthanit
    Watcharasit, Piyajit
    Rangkadilok, Nuchanart
    Thiantanawat, Apinya
    Satayavivad, Jutamaad
    TOXICOLOGY REPORTS, 2019, 6 : 426 - 430
  • [9] Cardioprotective Effects of the Ethanol Leaf Extract of Andrographis Paniculata in Isoproterenol- induced Myocardial Infarction in Rats
    Adedapo, Adeolu Alex
    Adeoye, Bisi Olajumoke
    Oyagbemi, Ademola Adetokunbo
    Omobowale, Temidayo Olutayo
    Yakubu, Momoh Audu
    FASEB JOURNAL, 2017, 31
  • [10] EVALUATION OF BENEFICIAL EFFECTS OF ANTIOXIDANT PROPERTIES OF AQUEOUS LEAF EXTRACT OF ANDROGRAPHIS PANICULATA IN STZ-INDUCED DIABETES
    Dandu, Anilkumar M.
    Inamdar, Naseeruddin M.
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 22 (01) : 49 - 52
12345