OPA1 in Cardiovascular Health and Disease

被引：18
|
作者：
Burke, Niall [1 ]
Hall, Andrew R. [1 ]
Hausenloy, Derek J. [1 ,2 ,3 ]
机构：
[1] UCL, Hatter Cardiovasc Inst, 67 Chenies Mews, London WC1E 6HX, England
[2] Duke NUS Grad Med Sch, Cardiovasc & Metab Disorders Program, Singapore, Singapore
[3] Natl Heart Ctr, Natl Heart Res Inst Singapore, Singapore, Singapore
来源：
CURRENT DRUG TARGETS | 2015年 / 16卷 / 08期
基金：
英国医学研究理事会;
关键词：
Cardiovascular disease; fission; fusion; mitochondrial morphology; OPA1; DOMINANT OPTIC ATROPHY; CYTOCHROME-C RELEASE; MITOCHONDRIAL PROTEASE OMA1; DYNAMIN-RELATED PROTEIN; PROTEOLYTIC CLEAVAGE; OXIDATIVE-PHOSPHORYLATION; RESPIRATORY-CHAIN; GTPASE OPA1; FUSION; MORPHOLOGY;
D O I：
10.2174/1389450116666150102113648
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype - processes which are under the regulation of the mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.
引用
收藏
页码：912 / 920
页数：9
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