Impact of transcranial Doppler sonography for detecting ischemic stroke A protocol of systematic review and meta-analysis

Background: This study aims to explore the impact of transcranial Doppler sonography (TDS) for detecting ischemic stroke (IS). Methods: PUBMED, EMBASE, Cochrane Library, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, WANGFANG, Chinese Biomedical Literature Database, and China National Knowledge In-frastructure will be utilized to examine case-controlled studies that used TDS for detecting IS. All electronic databases will be searched from inception to March 20, 2020. All study selection, data extraction, and study quality assessment will be carried out by 2 independent reviewers. All study quality will be assessed by Quality Assessment of Diagnostic Accuracy Studies tool, and statistical analysis will be performed by RevMan V.5.3 software and Stata V.12.0 software. Results: This study will explore the impact of TDS for detecting IS through sensitivity, specificity, positive and negative likelihood ratio, and diagnostic odds ratio. Conclusion : This study expects to find out whether TDS can be utilized for IS detection. Systematic review registration: INPLASY202040155.