Sulfo- and Oxy-analogues of Arginine: Synthesis, Analysis and Preliminary Biological Screening

被引：2

作者：

Dzimbova, Tatyana ^{[1
]}

Miladinova, Elisaveta ^{[1
]}

Mohr, Stefan ^{[2
]}

Decheva, Roumyana ^{[1
]}

Balacheva, Aneliya ^{[1
]}

Schmid, Martin G. ^{[2
]}

Pajpanova, Tamara ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Mol Biol, BG-1113 Sofia, Bulgaria

[2] Karl Franzens Univ Graz, Dept Pharmaceut Chem, Inst Pharmaceut Sci, A-8010 Graz, Austria

来源：

CROATICA CHEMICA ACTA | 2011年 / 84卷 / 03期

关键词：

canavanine; mimetics; polymer assisted synthesis; micro wave assisted synthesis; erythroleukemia cells; AMINO-ACIDS; LEUKOCYTE ADHESION; NITRIC-OXIDE; DERIVATIVES;

D O I：

10.5562/cca1780

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel methodology for the synthesis of sulfo- and oxy-modified amino acid analogues of arginine (Arg) has been developed using both conventional and polymer assisted synthesis from ready available amino acid precursor. Introduction of guanidine group was made also by the MWA synthesis. The in vitro inhibitory effect of the amino acid analogues on the growth of murine erythroleukemia cells, clone F4N in culture was also studied. (doi: 10.5562/cca1780)

引用

页码：447 / 453

页数：7

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