Confounders of excessive brain volume loss in schizophrenia

被引:56
|
作者
Van Haren, N. E. [1 ]
Cahn, W. [1 ]
Pol, H. E. Hulshoff [1 ]
Kahn, R. S. [1 ]
机构
[1] Univ Med Ctr Utrecht, Dept Psychiat, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands
来源
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2013年 / 37卷 / 10期
关键词
Schizophrenia; MRI; Brain volumes; Longitudinal; Antipsychotic medication; Cannabis; Outcome; CAUDATE NUCLEI VOLUMES; MATTER DENSITY CHANGES; 1ST EPISODE PSYCHOSIS; FOLLOW-UP; 1ST-EPISODE SCHIZOPHRENIA; CEREBROSPINAL-FLUID; VENTRICULAR ENLARGEMENT; PROGRESSIVE DECREASE; ONSET SCHIZOPHRENIA; HIPPOCAMPAL VOLUME;
D O I
10.1016/j.neubiorev.2012.09.006
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
There is convincing evidence that schizophrenia is characterised by progressive brain volume changes during the course of the illness. In a large longitudinal study it was shown that different age-related trajectories of brain tissue loss are present in patients compared to healthy subjects, suggesting that brain maturation that occurs in the third and fourth decade of life is abnormal in schizophrenia. However, studies show that medication intake and cannabis use are important confounding factors when interpreting brain volume (change) abnormalities. Indeed, continues use of cannabis, but not cigarette smoking, is associated to a more pronounced loss of grey matter in the anterior cingulated and the prefrontal cortex. Atypical antipsychotics have been found to be related to smaller decreases in tissue loss. Moreover, independent of antipsychotic medication intake, the brain volume abnormalities appear associated to the outcome of the illness. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2418 / 2423
页数:6
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