Association study of copy number variants with brain volume in schizophrenia patients and healthy controls

被引：6
|
作者：
van Scheltinga, Afke Terwisscha [1 ]
Bakker, Steven [1 ]
van Haren, Neeltje [1 ]
Buizer-Voskamp, Jacobine [1 ]
Boos, Heleen [1 ]
Vorstman, Jacob [1 ,2 ]
Cahn, Wiepke [1 ]
Pol, Hilleke Hulshoff [1 ]
Ophoff, Roel [2 ]
Kahn, Rene [1 ]
机构：
[1] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3584 CX Utrecht, Netherlands
[2] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA
来源：
PSYCHIATRY RESEARCH | 2012年 / 200卷 / 2-3期
关键词：
Imaging; Deletion; Duplication; DELETIONS;
D O I：
10.1016/j.psychres.2012.04.007
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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页码：1011 / 1013
页数：3
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