Association study of copy number variants with brain volume in schizophrenia patients and healthy controls

被引：6

作者：

van Scheltinga, Afke Terwisscha ^{[1
]}

Bakker, Steven ^{[1
]}

van Haren, Neeltje ^{[1
]}

Buizer-Voskamp, Jacobine ^{[1
]}

Boos, Heleen ^{[1
]}

Vorstman, Jacob ^{[1
,2
]}

Cahn, Wiepke ^{[1
]}

Pol, Hilleke Hulshoff ^{[1
]}

Ophoff, Roel ^{[2
]}

Kahn, Rene ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3584 CX Utrecht, Netherlands

[2] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA

来源：

PSYCHIATRY RESEARCH | 2012年 / 200卷 / 2-3期

关键词：

Imaging; Deletion; Duplication; DELETIONS;

D O I：

10.1016/j.psychres.2012.04.007

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

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页码：1011 / 1013

页数：3

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