Clay (Montmorillonite K10) catalysis of the Michael addition of α,β-unsaturated carbonyl compounds to indoles:: The beneficial role of alcohols

被引：0

作者：

Poupaert, JH ^{[1
]}

Bukuru, J ^{[1
]}

Gozzo, A ^{[1
]}

机构：

[1] Univ Catholique Louvain, Fac Med, Sch Pharm, B-1200 Brussels, Belgium

来源：

MONATSHEFTE FUR CHEMIE | 1999年 / 130卷 / 07期

关键词：

Michael addition; indole; Montmorillonite K10; alcohol;

D O I：

10.1007/PL00010274

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Michael addition of methylvinylketone to indole can be performed under smooth conditions by running the reaction in the presence of an acidic clay catalyst (K10 Montmorillonite) and an aliphatic alcohol such as ethanol or 2-propanol. Presence of an alcohol along with a polar solvent (nitromethane) in the reaction medium considerably improves the reaction.

引用

页码：929 / 932

页数：4