Tentative biosynthetic pathways of some microbial diketopiperazines

被引：34
|
作者：
Gu, Binbin [1 ]
He, Shan [1 ]
Yan, Xiaojun [1 ]
Zhang, Lixin [2 ]
机构：
[1] Ningbo Univ, Minist Educ, Key Lab Appl Marine Biotechnol, Ningbo 315211, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100190, Peoples R China
来源：
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2013年 / 97卷 / 19期
关键词：
Diketopiperazine; NRPS; CDPS; Biosynthetic gene clusters; NONRIBOSOMAL PEPTIDE SYNTHETASE; GENE-CLUSTER; CYCLIC DIPEPTIDES; ASPERGILLUS-FUMIGATUS; CYCLODIPEPTIDE SYNTHASES; PLANT PATHOGENICITY; ANTITUMOR-ACTIVITY; STRUCTURAL BASIS; THAXTOMIN-A; PENITREM-A;
D O I：
10.1007/s00253-013-5175-4
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cyclodipeptides and their derivatives, the diketopiperazines (DKPs), constitute a large class of natural products that exhibit various biological properties. Until recently, there are a few characterized DKP biosynthetic pathways. In all these cases, the formation of the cyclodipeptides that harbor the DKP scaffold is catalyzed either by nonribosomal peptide synthetases or by cyclodipeptide synthases. This review focuses on the DKP biosynthetic pathways and their associated molecular mechanisms.
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页码：8439 / 8453
页数：15
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