Evaluation of AAV Variants for Transgene Expression and Distribution in Rabbits and Non-Human Primate Eyes Following Intravitreal Delivery

被引：0
|
作者：
Iglesias, Bibiana Veronica [1 ]
Woodburn, Kathryn W. [2 ]
Cao, Jingtai [1 ]
Wiegand, Stanley J. [1 ]
Keravala, Annahita [2 ]
Romano, Carmelo [1 ]
Gasmi, Mehdi [2 ]
机构：
[1] Regeneron, Ophthalmol, Tarrytown, NY USA
[2] Avalanche Biotechnol, Menlo Pk, CA USA
来源：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2016年 / 57卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
786
引用
收藏
页数：3
相关论文
共 50 条
  • [21] AAV9, AAVrh.10, and AAVrh.74 Exhibit Different Cell Type Tropisms in the Heart Following Systemic Delivery and AAV9 Mediates Superior Cardiomyocyte Transgene Expression in Murine and Non-Human Primate Models
    Cheng, Ze
    Easter, Emilee
    Rollosson, Lindsey M.
    Xu, Emma
    Zhou, Huanyu
    Doerner, Karl
    Lin, JianMin
    Ivey, Kathryn N.
    Hoey, Timothy
    Lombardi, Laura M.
    MOLECULAR THERAPY, 2024, 32 (04) : 250 - 250
  • [22] Novel AAV Capsids Demonstrate Strong Retinal Expression in Non-Human Primates after Intravitreal Administration
    Kevany, Brian M.
    Suh, Susie
    Lu, Jennings
    Padegimas, Linas
    Palczewski, Krzysztof
    Miller, Timothy J.
    MOLECULAR THERAPY, 2019, 27 (04) : 113 - 113
  • [23] Immune-driven gene expression loss following intramuscular AAV delivery to non-human primates is only transient
    Journou, Malo
    Devaux, Marie
    Jaulin, Nicolas
    Pichard, Virginie
    Segovia, Mercedes
    Moreau, Aurelie
    Le Duff, Johanne
    Cuturi, Maria Cristina
    Guilbaud, Mickael
    Adjali, Oumeya
    MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT, 2025, 33 (01)
  • [24] Novel AAV Capsids Demonstrate Strong Retinal Expression in Non-Human Primates After Intravitreal Administration
    Kevany, Brian
    Suh, Susie
    Lu, Jennings
    Padegimas, Linas
    Palczewski, Krzysztof
    Miller, Timothy
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [25] Evaluation of Lateral Spread of Transgene Expression following Subretinal AAV-Mediated Gene Delivery in Dogs
    Bruewer, Ashlee R.
    Mowat, Freya M.
    Bartoe, Joshua T.
    Boye, Sanford L.
    Hauswirth, William W.
    Petersen-Jones, Simon M.
    PLOS ONE, 2013, 8 (04):
  • [26] Identification of Natural Human-Derived AAV2 Variants with Muscle Tropic Properties in Non-Human Primate Screens
    Zhang, Fang
    Cui, Mengtian
    McGowan, Jackson
    Wang, Dan
    Liang, Jialing Yang
    Gao, Guangping
    Tai, Phillip
    MOLECULAR THERAPY, 2024, 32 (04) : 115 - 116
  • [27] The effect of Surgical removal of the Internal Limiting Membrane on AAV vector delivery to the Retina in a Non-Human Primate model
    Teo, Kelvin
    Lee, Shu Yen
    Constable, Ian
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2018, 59 (09)
  • [28] Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6
    Towne, C.
    Schneider, B. L.
    Kieran, D.
    Redmond, D. E., Jr.
    Aebischer, P.
    GENE THERAPY, 2010, 17 (01) : 141 - 146
  • [29] Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6
    C Towne
    B L Schneider
    D Kieran
    D E Redmond
    P Aebischer
    Gene Therapy, 2010, 17 : 141 - 146
  • [30] Transgene Expression and Tolerability After a Secondary Subretinal Injection of an AAV Vector to the Ipsilateral Eye in Non-Human Primates
    Newmark, Judith
    Timmers, Adrian
    Boyd, Ryan
    Vihtelic, Thomas
    Shearman, Mark
    MOLECULAR THERAPY, 2020, 28 (04) : 88 - 88
12345