MAPK and PI3K signaling: At the crossroads of neural crest development

被引：47

作者：

Dinsmore, Colin J. ^{[1
]}

Soriano, Philippe ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Cell Dev & Regenerat Biol, New York, NY 10029 USA

来源：

DEVELOPMENTAL BIOLOGY | 2018年 / 444卷

关键词：

Receptor Tyrosine kinases; ERK; AKT; Cell signaling; ACTIVATED PROTEIN-KINASE; GROWTH-FACTOR RECEPTOR; SERUM RESPONSE FACTOR; REGULATES CRANIOFACIAL DEVELOPMENT; ENTERIC NEUROBLASTS REQUIRE; C-JUN; CELL-PROLIFERATION; TYROSINE KINASES; MICE LACKING; PDGFR-ALPHA;

D O I：

10.1016/j.ydbio.2018.02.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Receptor tyrosine kinase-mediated growth factor signaling is essential for proper formation and development of the neural crest. The many ligands and receptors implicated in these processes signal through relatively few downstream pathways, frequently converging on the MAPK and PI3K pathways. Despite decades of study, there is still considerable uncertainty about where and when these signaling pathways are required and how they elicit particular responses. This review summarizes our current understanding of growth factor -induced MAPK and PI3K signaling in the neural crest.

引用

页码：S79 / S97

页数：19

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