Caenorhabditis elegans as a model system for human diseases

被引：72
|
作者：
Markaki, Maria [1 ]
Tavernarakis, Nektarios [1 ,2 ]
机构：
[1] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Iraklion 70013, Crete, Greece
[2] Univ Crete, Sch Med, Dept Basic Sci, Iraklion 70013, Crete, Greece
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2020年 / 63卷
基金：
欧洲研究理事会;
关键词：
ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CELL-DEATH; C-ELEGANS; TAU; AGGREGATION; GENETICS; SUSCEPTIBILITY; NEUROTOXICITY;
D O I：
10.1016/j.copbio.2019.12.011
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The nematode Caenorhabditis elegans offers unique advantages that enable a comprehensive delineation of the cellular and molecular mechanisms underlying devastating human pathologies such as stroke, ischemia and age-associated neurodegenerative disorders. Genetic models of human diseases that closely simulate several disease-related phenotypes have been established in the worm. These models allow the implementation of multidisciplinary approaches, in addition to large-scale genetic and pharmacological screenings, designed to elucidate the molecular mechanisms mediating pathogenesis and to identify targets and drugs for emergent therapeutic interventions. Such strategies have already provided valuable insights, highly relevant to human health and quality of life. This article considers the potential of C. elegans as a versatile platform for systematic dissection of the molecular basis of human disease, focusing on neurodegenerative disorders.
引用
收藏
页码：118 / 125
页数：8
相关论文
共 50 条
  • [21] Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin
    Andrea Henze
    Thomas Homann
    Isabelle Rohn
    Michael Aschner
    Christopher D. Link
    Burkhard Kleuser
    Florian J. Schweigert
    Tanja Schwerdtle
    Julia Bornhorst
    Scientific Reports, 6
  • [22] Using Caenorhabditis elegans as a Model for Aging and Age-Related Diseases
    Olsen, Anders
    Vantipalli, Maithili C.
    Lithgow, Gordon J.
    UNDERSTANDING AND MODULATING AGING, 2006, 1067 : 120 - 128
  • [23] Caenorhabditis Elegans as a Model System to Study Intercompartmental Proteostasis: Interrelation of Mitochondrial Function, Longevity, and Neurodegenerative Diseases
    Kirstein-Miles, Janine
    Morimoto, Richard I.
    DEVELOPMENTAL DYNAMICS, 2010, 239 (05) : 1529 - 1538
  • [24] Glutathione synthesis in parasitic nematodes:: Caenorhabditis elegans as a model system
    Ajonina, C
    Sommer, A
    Lüersen, K
    Liebau, E
    Walter, RD
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2004, 293 : 109 - 110
  • [25] CAENORHABDITIS-ELEGANS - A MODEL SYSTEM FOR SPACE BIOLOGY STUDIES
    JOHNSON, TE
    NELSON, GA
    EXPERIMENTAL GERONTOLOGY, 1991, 26 (2-3) : 299 - 309
  • [26] Left–right asymmetry in the nervous system: the Caenorhabditis elegans model
    Oliver Hobert
    Robert J. Johnston
    Sarah Chang
    Nature Reviews Neuroscience, 2002, 3 : 629 - 640
  • [27] Drug combination assays using Caenorhabditis elegans as a model system
    Hernando, Guillermina
    Bouzat, Cecilia
    JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2025, 131
  • [28] Caenorhabditis elegans as a model system to study aging of learning and memory
    Murakami, Shin
    MOLECULAR NEUROBIOLOGY, 2007, 35 (01) : 85 - 94
  • [29] The nematode Caenorhabditis elegans as a model system for studying mechanisms of toxicity
    Mee, CJ
    de Pomerai, DI
    Usherwood, PNR
    Bell, DR
    TOXICOLOGY, 2001, 168 (01) : 56 - 57
  • [30] Caenorhabditis elegans as a model system to study aging of learning and memory
    Murakami S.
    Molecular Neurobiology, 2007, 35 (1) : 85 - 94
12345