Asymmetric total synthesis of 5′-epi-paecilomycin-F

被引：25

作者：

Jana, Nandan ^{[1
]}

Nanda, Samik ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India

来源：

TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 10期

关键词：

RESORCYLIC ACID LACTONES; DYNAMIC KINETIC RESOLUTION; KINASE INHIBITOR; AIGIALOMYCIN-D; ESTROGENIC ACTIVITY; RUTHENIUM; RADICICOL; LL-Z1640-2; ALCOHOLS; MACROLIDES;

D O I：

10.1016/j.tetasy.2012.05.017

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric total synthesis of one of the stereoisomers of the naturally occurring 14-membered ring macrolide paecilomycin-F (5'-epi) has been reported in this article. The main highlight of the synthetic strategy involves the successful application of a ring closing metathesis (RCM) reaction at a late stage. Asymmetric Keck allylation, Sharpless asymmetric dihydroxylation, and Mitsunobu esterification have also been used successfully for the total synthesis of 5'-epi-paecilomycin-F. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：802 / 808

页数：7

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