Stereoselective total synthesis of paecilomycin E and F and its two congeners Cochliomycin C and 6-epi-Cochliomycin C

被引：3

作者：

Kadari, Sudhakar ^{[1
]}

Yerrabelly, Hemasri ^{[1
]}

Yerrabelly, Jayaprakash Rao ^{[1
]}

Gogula, Thirupathi ^{[1
]}

Goud, Yadaiah ^{[1
]}

Thalari, Gangadhar ^{[1
]}

Doda, Sai Reddy ^{[2
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad, Telangana, India

[2] CSIR Indian Inst Chem Technol, Nat Prod Chem Div, Hyderabad, Telangana, India

来源：

SYNTHETIC COMMUNICATIONS | 2018年 / 48卷 / 14期

关键词：

C-C coupling; Grignard reaction; macrolactonisation; natural products; olefin metathesis; total synthesis; RESORCYLIC ACID LACTONES; STEREOSPECIFIC TOTAL-SYNTHESIS; 1ST TOTAL-SYNTHESIS; STRUCTURE REVISION; MONOCILLIN-I; RUGULACTONE; METABOLITES; RADICICOL;

D O I：

10.1080/00397911.2018.1472282

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and concise approach to the total synthesis of Paecilomycins E (1) and F (2), Cochliomycin C (4) and 6-epi-Cochliomycin C (3) is described. The synthesis involves novel route to the synthesis of Paecilomycin E and F and further conversion to Cochliomycin C and 6-epi-Cochliomycin C. Olefin metathesis and base promoted macro lactonization being the key reactions followed by chlorination to achieve target Cochliomycin C and 6-epi-Cochliomycin C. [GRAPHICS] .

引用

页码：1867 / 1875

页数：9

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