Flavonoids from Artemisia sacrorum Ledeb. and their cytotoxic activities against human cancer cell lines

被引：27
|
作者：
Yuan, Haidan [1 ,2 ]
Lu, Xuyang [3 ]
Ma, Qianqian [1 ]
Li, Di [1 ]
Xu, Guanghua [1 ]
Piao, Guangchun [1 ,2 ]
机构：
[1] Yanbian Univ, Dept Pharmacognosy, Coll Pharm, 977 Gongyuan Rd, Yanji 133000, Jilin, Peoples R China
[2] Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Yanji 133000, Jilin, Peoples R China
[3] Jilin Cent Hosp, Dept Pharm, Jilin 132000, Jilin, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2016年 / 12卷 / 03期
关键词：
Artemisia sacrorum Ledeb; flavonoids; cytotoxic activities; human cancer cell lines; ACTIVE PART; CYCLE ARREST; IN-VITRO; PROLIFERATION; CONSTITUENTS; APOPTOSIS; SCUTELLARIA;
D O I：
10.3892/etm.2016.3556
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Flavonoids have been demonstrated to have cytotoxic activities toward numerous human cancer cells, whereas they have little or no effect on normal cells. The numerous flavonoids in traditional Chinese herbs may be promising candidates for the development of novel anti-cancer drugs. Our previous study demonstrated that CH2Cl2 and 95% ethanol eluate (EE) fractions have the strongest cytotoxic activities against human cancer cell lines of the 9 fractions separated from Artemisia sacrorum Ledeb., which is widely used to prevent and treat diverse diseases in Northeast China. In the present study, 8 flavonoids were isolated from the 95% EE fraction of Artemisia sacrorum Ledeb. The chemical structures of the compounds were elucidated by extensive spectroscopic analyses. The following 5 flavonoids were isolated for the first time from this plant: Jaceosidin, kaempferol, quercetin, luteolin and quercitrin. A total of 2 flavonoids from the CH2Cl2 fraction and 8 flavonoids from the 95% EE fraction were examined to evaluate their cytotoxic activities against human SK-HEP-1 hepatoma cancer cells and human HeLa cervical cancer cells, respectively. The results revealed that 2 flavonoids had marked cytotoxic activities against HeLa cells.
引用
收藏
页码：1873 / 1878
页数：6
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