Diterpenes from the berries of Juniperus excelsa

被引：92
|
作者：
Topçu, G
Erenler, R
Çakmak, O
Johansson, CB
Çelik, C
Chai, HB
Pezzuto, JM
机构：
[1] TUBITAK, Marmara Res Ctr, Dept Chem, TR-41470 Gebze, Kocaeli, Turkey
[2] Gaziosmanpasa Univ, Fac Art & Sci, Dept Chem, TR-60100 Tokat, Turkey
[3] Univ Marmara, Fac Med, Dept Microbiol, Istanbul, Turkey
[4] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
来源：
PHYTOCHEMISTRY | 1999年 / 50卷 / 07期
关键词：
Juniperus excelsa; Cupressaceae; berries; diterpenes; juniperexcelsic acid; sesquiterpene; cytotoxic; antituberculosis and antibacterial activity;
D O I：
10.1016/S0031-9422(98)00675-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
From the hexane extract of berries of Juniperus excelsa, one new and four known diterpenes were isolated besides a known sesquiterpene. The structures of the known diterpenes were identified as isopimaric, isocommunic, (-)ent-trans communic and sandracopimaric acids, along with the sesquiterpene 4a-hydroxycedrol and the new compound which was elucidated as 3 alpha-acetoxylabda-8(17), 13(16), 14-trien-19-oic acid (juniperexcelsic acid). Cytotoxic activity of the hexane extract was investigated against a panel of cell line and found highyl active against LNCaP, KB-V (+VLB) and KB-V (-VLB) cell lines. Furthermore, the hexane and methanol extracts, and the new compound were found to be moderately active against Mycobacterium tuberculosis. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1195 / 1199
页数：5
相关论文
共 50 条
  • [31] Oxygenated diterpenes and other constituents from Moroccan Juniperus phoenicea and Juniperus thurifera var. africana
    Barrero, AF
    del Moral, JF
    Herrador, MM
    Akssira, M
    Bennamara, A
    Akkad, S
    Aitigri, M
    PHYTOCHEMISTRY, 2004, 65 (17) : 2507 - 2515
  • [32] Morphological versus molecular markers to describe variability in Juniperus excelsa subsp excelsa (Cupressaceae)
    Douaihy, Bouchra
    Sobierajska, Karolina
    Jasinska, Anna Katarzyna
    Boratynska, Krystyna
    Ok, Tolga
    Romo, Angel
    Machon, Nathalie
    Didukh, Yakiv
    Dagher-Kharrat, Magda Bou
    Boratynski, Adam
    AOB PLANTS, 2012,
  • [33] SHOOT REGENERATION FROM SHOOT TIP EXPLANTS OF JUNIPERUS EXCELSA BIEB.
    Rifaki, Nikoleta
    Economou, Athanasios Sotirios
    Hatzilazarou, Stefanos
    Hatzistathis, Athanasios
    PROPAGATION OF ORNAMENTAL PLANTS, 2009, 9 (01): : 53 - 55
  • [34] Composition and antimicrobial activity of Juniperus excelsa essential oil
    M. Unlu
    G. Vardar-Unlu
    N. Vural
    E. Donmez
    O. Cakmak
    Chemistry of Natural Compounds, 2008, 44
  • [35] 7 NEW LABDANE DITERPENES FROM JUNIPERUS-PSEUDOSABINA HOOK
    PANDITA, K
    AGARWAL, SG
    THAPPA, RK
    DHAR, KL
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1987, 26 (05): : 453 - 458
  • [36] Dehydroabietane diterpenes from Juniperus formosana Hay var Concolor Hay
    Kuo, YH
    Yu, MT
    PHYTOCHEMISTRY, 1996, 42 (03) : 779 - 781
  • [37] Composition and antimicrobial activity of Juniperus excelsa essential oil
    Unlu, M.
    Vardar-Unlu, G.
    Vural, N.
    Donmez, E.
    Cakmak, O.
    CHEMISTRY OF NATURAL COMPOUNDS, 2008, 44 (01) : 129 - 131
  • [38] Diterpenes from the heartwood of Juniperus formosana Hay var concolor Hay
    Kuo, YH
    Yu, MT
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1996, 44 (08) : 1431 - 1435
  • [39] The composition of volatile extractives from the wood of Juniperus excelsa, Juniperus foetidissima and Juniperus oxycedrusDie Zusammensetzung der flüchtigen Extraktstoffe im Holz von Juniperus foetidissima und Juniperus oxycedrus
    G. Uçar
    M. Balaban
    Holz als Roh- und Werkstoff, 2002, 60 : 356 - 362
  • [40] Composition and variability of the essential oils of the leaves and berries from Juniperus navicularis
    Cavaleiro, C
    Salgueiro, LR
    da Cunha, A
    Figueiredo, AC
    Barroso, JG
    Bighelli, A
    Casanova, J
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2003, 31 (02) : 193 - 201
12345