Diterpenes from the berries of Juniperus excelsa

被引：86

作者：

Topçu, G

Erenler, R

Çakmak, O

Johansson, CB

Çelik, C

Chai, HB

Pezzuto, JM

机构：

[1] TUBITAK, Marmara Res Ctr, Dept Chem, TR-41470 Gebze, Kocaeli, Turkey

[2] Gaziosmanpasa Univ, Fac Art & Sci, Dept Chem, TR-60100 Tokat, Turkey

[3] Univ Marmara, Fac Med, Dept Microbiol, Istanbul, Turkey

[4] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

来源：

PHYTOCHEMISTRY | 1999年 / 50卷 / 07期

关键词：

Juniperus excelsa; Cupressaceae; berries; diterpenes; juniperexcelsic acid; sesquiterpene; cytotoxic; antituberculosis and antibacterial activity;

D O I：

10.1016/S0031-9422(98)00675-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the hexane extract of berries of Juniperus excelsa, one new and four known diterpenes were isolated besides a known sesquiterpene. The structures of the known diterpenes were identified as isopimaric, isocommunic, (-)ent-trans communic and sandracopimaric acids, along with the sesquiterpene 4a-hydroxycedrol and the new compound which was elucidated as 3 alpha-acetoxylabda-8(17), 13(16), 14-trien-19-oic acid (juniperexcelsic acid). Cytotoxic activity of the hexane extract was investigated against a panel of cell line and found highyl active against LNCaP, KB-V (+VLB) and KB-V (-VLB) cell lines. Furthermore, the hexane and methanol extracts, and the new compound were found to be moderately active against Mycobacterium tuberculosis. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1195 / 1199

页数：5

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