Effect of prostaglandin E2 infusion on the course of arterial hypertension in spontaneously hypertensive rats

被引：0
|
作者：
Runikhin, AY [1 ]
Savchuk, VI [1 ]
Sokolova, RI [1 ]
Levitskaya, YV [1 ]
Pocheptsova, GA [1 ]
Arabidze, GG [1 ]
机构：
[1] Russian Cardiol Sci Ind Complex, Cardiol Res Ctr, Moscow 121552, Russia
来源：
KARDIOLOGIYA | 1999年 / 39卷 / 09期
关键词：
hypertension; prostaglandin E-2; reflexes; pressor; depressor; spontaneously hypertensive rats;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Effect of prolonged intravenous infusions of exogenous prostaglandin E-2 on the course of arterial hypertension was studied in Okamoto-Aoki spontaneously hypertensive rats. Prostaglandin E-2 produced favorable effect on the course of hypertension. Stable lowering of blood pressure achieved by infusions of prostaglandin E-2 persisted for several months after their cessation. Changes of baroreflex blood pressure regulation and biosynthesis of endogenous renal prostaglandins were also observed. Infusions of prostaglandin E-2 improved blood supply to target organs and induced vasodilation in renal parenchyma, myocardium and brain.
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页码：63 / 67
页数：5
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