Effect of prostaglandin E2 infusion on the course of arterial hypertension in spontaneously hypertensive rats

被引：0

作者：

Runikhin, AY ^{[1
]}

Savchuk, VI ^{[1
]}

Sokolova, RI ^{[1
]}

Levitskaya, YV ^{[1
]}

Pocheptsova, GA ^{[1
]}

Arabidze, GG ^{[1
]}

机构：

[1] Russian Cardiol Sci Ind Complex, Cardiol Res Ctr, Moscow 121552, Russia

来源：

KARDIOLOGIYA | 1999年 / 39卷 / 09期

关键词：

hypertension; prostaglandin E-2; reflexes; pressor; depressor; spontaneously hypertensive rats;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Effect of prolonged intravenous infusions of exogenous prostaglandin E-2 on the course of arterial hypertension was studied in Okamoto-Aoki spontaneously hypertensive rats. Prostaglandin E-2 produced favorable effect on the course of hypertension. Stable lowering of blood pressure achieved by infusions of prostaglandin E-2 persisted for several months after their cessation. Changes of baroreflex blood pressure regulation and biosynthesis of endogenous renal prostaglandins were also observed. Infusions of prostaglandin E-2 improved blood supply to target organs and induced vasodilation in renal parenchyma, myocardium and brain.

引用

页码：63 / 67

页数：5

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