Mechanisms and emerging functions of DNA degradation in the epidermis

被引：19
|
作者：
Eckhart, Leopold [1 ]
Fischer, Heinz [1 ]
Tschachler, Erwin [1 ,2 ]
机构：
[1] Med Univ Vienna, Dept Dermatol, Res Div Biol & Pathobiol Skin, A-1090 Vienna, Austria
[2] CE RIES, Neuilly Sur Seine, France
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷
基金：
奥地利科学基金会;
关键词：
Epidermis; Endonuclease; Exonuclease; Stratum Corneum; Apoptosis; Psoriasis; Antimicrobial Defense; Biofilm; Inflammation; Review; SINGLE NUCLEOTIDE POLYMORPHISMS; CASPASE-ACTIVATED DNASE; I-LIKE; STRATUM-CORNEUM; DEOXYRIBONUCLEASE-II; CELL-DEATH; SKIN CARCINOGENESIS; EXONUCLEASE TREX1; SALINE EXTRACTS; NUCLEAR-DNA;
D O I：
10.2741/4065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Degradation of DNA is involved in key processes maintaining the integrity of the epidermis such as the cornification of keratinocytes, the removal of damaged cells and the defense against potentially harmful microorganisms. Recent studies have characterized some of the molecular mechanisms and physiological functions of DNA degradation in the epidermis. Deoxyribonuclease (DNase)1L2 and TREX2 were identified as epidermis-specific DNases and DNase 2 was shown to be the predominant DNA-degrading enzyme on the surface of the skin. Here we review the latest insights into the DNA catabolism in the skin and discuss open questions pertaining to the molecular biology of epidermal DNA breakdown.
引用
收藏
页码：2461 / 2475
页数：15
相关论文
共 50 条
  • [31] Ubiquitination in Cancer Metastasis: Emerging Functions, Underlying Mechanisms, and Clinical Implications
    Barik, Ganesh Kumar
    Sahay, Osheen
    Islam, Sehbanul
    Ghate, Nikhil Baban
    Kalita, Bhargab
    Alam, Aftab
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2023, 22
  • [32] Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets
    Jeon, Soyoung
    Jeon, Yeram
    Lim, Ji-Youn
    Kim, Yujeong
    Cha, Boksik
    Kim, Wantae
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2025, 10 (01)
  • [33] Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases
    Lu, Fangfang
    Lan, Zhixin
    Xin, Zhaoqi
    He, Chunrong
    Guo, Zimeng
    Xia, Xiaobo
    Hu, Tu
    JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (04) : 3207 - 3221
  • [34] Plastid Inheritance Revisited: Emerging Role of Organelle DNA Degradation in Angiosperms
    Sakamoto, Wataru
    Takami, Tsuneaki
    PLANT AND CELL PHYSIOLOGY, 2024, 65 (04) : 484 - 492
  • [35] The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions
    Tessmer, Ingrid
    Margison, Geoffrey P.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (01)
  • [36] Mechanisms of Mitochondrial DNA Degradation and Repair in Response to Genotoxic Stress
    Zhao, Linlin
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2024, 65 : 55 - 56
  • [37] Mechanisms of degradation of DNA standards for calibration function during storage
    Rossmanith, Peter
    Roeder, Barbara
    Fruehwirth, Karin
    Vogl, Claus
    Wagner, Martin
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 89 (02) : 407 - 417
  • [38] The emerging roles of serine protease cascades in the epidermis
    Ovaere, Petra
    Lippens, Saskia
    Vandenabeele, Peter
    Declercq, Wim
    TRENDS IN BIOCHEMICAL SCIENCES, 2009, 34 (09) : 453 - 463
  • [39] Mechanisms of degradation of DNA standards for calibration function during storage
    Peter Rossmanith
    Barbara Röder
    Karin Frühwirth
    Claus Vogl
    Martin Wagner
    Applied Microbiology and Biotechnology, 2011, 89 : 407 - 417
  • [40] CONTROL OF DNA BIOSYNTHESIS IN EPIDERMIS
    LEWIS, RA
    KARASEK, MA
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1969, 52 (04) : 377 - &
12345