Mechanisms and emerging functions of DNA degradation in the epidermis

被引：19
|
作者：
Eckhart, Leopold [1 ]
Fischer, Heinz [1 ]
Tschachler, Erwin [1 ,2 ]
机构：
[1] Med Univ Vienna, Dept Dermatol, Res Div Biol & Pathobiol Skin, A-1090 Vienna, Austria
[2] CE RIES, Neuilly Sur Seine, France
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷
基金：
奥地利科学基金会;
关键词：
Epidermis; Endonuclease; Exonuclease; Stratum Corneum; Apoptosis; Psoriasis; Antimicrobial Defense; Biofilm; Inflammation; Review; SINGLE NUCLEOTIDE POLYMORPHISMS; CASPASE-ACTIVATED DNASE; I-LIKE; STRATUM-CORNEUM; DEOXYRIBONUCLEASE-II; CELL-DEATH; SKIN CARCINOGENESIS; EXONUCLEASE TREX1; SALINE EXTRACTS; NUCLEAR-DNA;
D O I：
10.2741/4065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Degradation of DNA is involved in key processes maintaining the integrity of the epidermis such as the cornification of keratinocytes, the removal of damaged cells and the defense against potentially harmful microorganisms. Recent studies have characterized some of the molecular mechanisms and physiological functions of DNA degradation in the epidermis. Deoxyribonuclease (DNase)1L2 and TREX2 were identified as epidermis-specific DNases and DNase 2 was shown to be the predominant DNA-degrading enzyme on the surface of the skin. Here we review the latest insights into the DNA catabolism in the skin and discuss open questions pertaining to the molecular biology of epidermal DNA breakdown.
引用
收藏
页码：2461 / 2475
页数：15
相关论文
共 50 条
  • [1] The emerging mechanisms and functions of microautophagy
    Wang, Liming
    Klionsky, Daniel J.
    Shen, Han-Ming
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2023, 24 (03) : 186 - 203
  • [2] The emerging mechanisms and functions of microautophagy
    Liming Wang
    Daniel J. Klionsky
    Han-Ming Shen
    Nature Reviews Molecular Cell Biology, 2023, 24 : 186 - 203
  • [3] Placental imprinting: Emerging mechanisms and functions
    Hanna, Courtney W.
    PLOS GENETICS, 2020, 16 (04):
  • [4] Emerging regulatory mechanisms and functions of autophagy in fish
    Xia, Xiaojing
    Wang, Xin
    Qin, Wanhai
    Jiang, Jinqing
    Cheng, Likun
    AQUACULTURE, 2019, 511
  • [5] Lysine acetylation in cyanobacteria: emerging mechanisms and functions
    Liu, Xin
    Yang, Mingkun
    Ge, Feng
    Zhao, Jindong
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2025,
  • [6] Inflammasome Complexes: Emerging Mechanisms and Effector Functions
    Rathinam, Vijay A. K.
    Fitzgerald, Katherine A.
    CELL, 2016, 165 (04) : 792 - 800
  • [7] Emerging mechanisms of eukaryotic DNA replication initiation
    Leatherwood, J
    CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (06) : 742 - 748
  • [8] Mechanisms and functions of DNA mismatch repair
    Li, Guo-Min
    CELL RESEARCH, 2008, 18 (01) : 85 - 98
  • [9] DNA mismatch repair: Functions and mechanisms
    Iyer, RR
    Pluciennik, A
    Burdett, V
    Modrich, PL
    CHEMICAL REVIEWS, 2006, 106 (02) : 302 - 323
  • [10] Mechanisms and functions of DNA mismatch repair
    Guo-Min Li
    Cell Research, 2008, 18 : 85 - 98
12345