Asymmetric addition of dimethylzinc to N-tosylarylimines catalyzed by a rhodium-diene complex toward the synthesis of chiral 1-arylethylamines

被引：73
|
作者：
Nishimura, T [1 ]
Yasuhara, Y [1 ]
Hayashi, T [1 ]
机构：
[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 05期
关键词：
D O I：
10.1021/ol060213e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rhodium complex coordinated with a chiral diene, (RR)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene (Ph-bod*), catalyzed the asymmetric addition of dimethylzinc to N-tosylarylimines to give high yields of chiral 1-aryl-1-ethylamines with high enantioselectivity (94-98% ee).
引用
收藏
页码：979 / 981
页数：3
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