Relationship between NF-κB1-94 ins/del ATTG polymorphism and susceptibility of multiple sclerosis in Iranian MS patients

Multiple sclerosis (MS) is one of the most common neurological diseases of the central nervous system (CNS) which is mediated by the autoimmune reactions against myelin sheath. Both genetic and environmental factors are thought to be involved in the pathogenesis of MS. NF-kappa B1 is one of the most important molecules which regulates the immune functions. NF-kappa B1 -94 ins/del ATTG promoter polymorphism is a well-studied region in NF-kappa B1 gene associated with several common autoimmune diseases such as systemic lupus erythematosus (SLE). Our hypothesis was aimed to address the potential association of NF-kappa B polymorphism and MS. Therefore, we analyzed 200 sex and age matched MS patients along with 200 healthy individuals using PCR-RFLP. The data revealed no significant differences in the frequency of the -94 ins/del ATTG polymorphism in multiple sclerosis patients compared with the control group. To conclude, our study showed no association between -94 ins/del ATTG polymorphism and risk of multiple sclerosis in Iranian patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.