NMR assignment and secondary structure of human growth arrest and DNA damage α protein (Gadd45α)

被引：4

作者：

Sanchez, Ricardo ^{[1
]}

Pantoja-Uceda, David ^{[2
]}

Torres, Daniel ^{[3
]}

Prieto, Jesus ^{[3
]}

Campos-Olivas, Ramon ^{[3
]}

Blanco, Francisco J. ^{[1
]}

机构：

[1] CIC Biogune, Struct Biol Unit, Derio 48160, Spain

[2] CSIC, Inst Quim Fis Rocasolano, Mol Struct & Spect Dept, E-28006 Madrid, Spain

[3] CNIO, Struct & Computat Biol Programme, Madrid 28029, Spain

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2008年 / 2卷 / 02期

关键词：

Gadd45; DNA damage; Growth arrest; Selective labeling; NMR assignment;

D O I：

10.1007/s12104-008-9105-9

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Gadd45 alpha is a predominantly nuclear protein encoded by a DNA-damage-inducible gene which is transcriptionally regulated by the tumor suppressor p53. The interactions of Gadd45 alpha with several other proteins play a central role in DNA repair, cell cycle control and apoptosis. The NMR assignments of human Gadd45 alpha protein reported here provide the basis for further characterization of these interactions.

引用

页码：139 / 142

页数：4

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