High Hepsin expression predicts poor prognosis in Gastric Cancer

被引：13
|
作者：
Zhang, Mingming [1 ]
Zhao, Junjie [2 ]
Tang, Wenyi [1 ]
Wang, Yanru [3 ]
Peng, Peike [1 ]
Li, Lili [1 ]
Song, Shushu [1 ]
Wu, Hao [1 ]
Li, Can [1 ]
Yang, Caiting [1 ]
Wang, Xuefei [2 ]
Zhang, Chunyi [1 ]
Gu, Jianxin [1 ]
机构：
[1] Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Shanghai 200032, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China
[3] Fudan Univ, Sch Basic Med Sci, Dept Anat & Histol & Embryol, Shanghai 200032, Peoples R China
来源：
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词：
HEPATOCYTE GROWTH-FACTOR; SURFACE SERINE-PROTEASE; GENE-EXPRESSION; N-GLYCOSYLATION; PROSTATE-CANCER; FACTOR-VII; OVEREXPRESSION; DOMAIN; PROTEINASES; PROGRESSION;
D O I：
10.1038/srep36902
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Hepsin, a membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression. Our study aims to describe the expression pattern and evaluate the clinical implication of hepsin in gastric cancer patients. The mRNA expression of hepsin was analyzed in 50 gastric cancer and matched non-tumor tissues, which was downregulated in 78% (39/50) of gastric cancer. By searching and analyzing four independent datasets from Oncomine, we obtained the similar results. Furthermore, we evaluated the hepsin expression by IHC in tissue microarray (TMA) containing 220 Gastric Cancer specimens. More importantly, Kaplan-Meier survival and Cox regression analyses were taken to access the prognosis of gastric cancer and predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer.
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收藏
页数：10
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