Quantum cascade laser-based sensor for detection of exhaled and biogenic nitric oxide

被引：32

作者：

Marchenko, D. ^{[1
]}

Mandon, J. ^{[1
]}

Cristescu, S. M. ^{[1
]}

Merkus, P. J. F. M. ^{[2
]}

Harren, F. J. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Life Sci Trace Gas Facil, Inst Mol & Mat, NL-6500 GL Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Pediat Pulmonol, NL-6500 HB Nijmegen, Netherlands

来源：

APPLIED PHYSICS B-LASERS AND OPTICS | 2013年 / 111卷 / 03期

关键词：

DEAD SPACE VOLUME; HUMAN SKIN; SPECTROSCOPIC DETECTION; CARBON-DIOXIDE; NO; ALVEOLAR; RELEASE; AIRWAYS;

D O I：

10.1007/s00340-013-5341-5

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A sensor based on a continuous wave quantum cascade laser, operating near 5.2 mu m, in combination with integrated cavity output spectroscopy has been developed for simultaneous measurement of nitric oxide (NO) and carbon dioxide (CO2) traces in exhaled air. A detection limit of 0.7 parts-per-billion by volume of NO (acquisition time: 1 s) is achieved. Comparison is made with the standard chemiluminescence NO analyzer and commercial CO2 breath sampler. The QCL-based sensor is tested on healthy subjects at various exhalation flow rates (15, 50, 100 and 300 ml/s) for both online and offline sampling procedures as well as on asthmatic children (offline sampling). Possibilities for measurements of biogenic NO in vivo, i.e., NO coming from human skin tissue, are also demonstrated.

引用

页码：359 / 365

页数：7

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