Soluble amyloid precursor proteins and secretases as Alzheimer's disease biomarkers

被引：35

作者：

Perneczky, Robert ^{[1
,2
,3
]}

Alexopoulos, Panagiotis ^{[3
]}

Kurz, Alexander ^{[3
]}

机构：

[1] Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, London W6 8RP, England

[2] West London Mental Hlth Trust, West London Cognit Disorders Treatment & Res Unit, London TW8 8DS, England

[3] Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 01期

关键词：

biomarker; amyloid precursor protein; Alzheimer's disease; dementia; secretase; early diagnosis; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID BIOMARKERS; SORTILIN-RELATED RECEPTOR; BETA-SECRETASE; ALPHA-SECRETASE; BACE1; ACTIVITY; NATIONAL INSTITUTE; CLEAVING ENZYME; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES;

D O I：

10.1016/j.molmed.2013.10.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently revised diagnostic guidelines for Alzheimer's disease (AD) emphasise the use of biomarkers, heralding a paradigm shift towards a more biological definition of the disorder. Currently available biomarkers offer added diagnostic accuracy in certain situations, but their performance in terms of early diagnostic sensitivity and specificity does not fully live up to the desired standards. One feasible approach to improve the diagnostic and prognostic performance of AD biomarkers is to measure upstream events of amyloid precursor protein (APP) processing, which are at the core of the initial phase of AD pathogenesis. Here we review evidence on the APP processing enzymes and their cleavage products and discuss possible applications and limitations in their use as AD biomarkers.

引用

页码：8 / 15

页数：8

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