Restoration of function by glial cell transplantation into demyelinated spinal cord

被引：21
|
作者：
Kocsis, JD [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Neurol, Neurosci Res Ctr, West Haven, CT 06516 USA
[2] VA Med Ctr, Neurosci Res Ctr, West Haven, CT USA
来源：
JOURNAL OF NEUROTRAUMA | 1999年 / 16卷 / 08期
关键词：
spinal cord injury; transplantation; Schwann cell; glial cell; olfactory ensheathing cell; genetically engineered cells; remyelination; electrophysiological function;
D O I：
10.1089/neu.1999.16.695
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Transplantation of myelin-forming cells into the demyelinated spinal cord results in remyelination. This paper reviews the electrophysiological properties of demyelinated axons remyelinated by transplantation of myelin-forming cells. Conduction velocity and frequency-response properties of the remyelinated axons are restored to near normal values. Moreover, conduction block can be overcome by remyelination, and no abnormal firing is observed. There is discussion of the challenges of a potential cell therapy approach in human demyelinating disease.
引用
收藏
页码：695 / 703
页数：9
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