Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives

被引：22
|
作者：
Mickevicius, Vytautas [1 ]
Voskiene, Ausra [1 ]
Jonuskiene, Ilona [1 ]
Kolosej, Ramune [1 ]
Siugzdaite, Jurate [2 ]
Venskutonis, Petras Rimantas [3 ]
Kazernaviciute, Rita [3 ]
Braziene, Zita [4 ]
Jakiene, Elena [5 ]
机构：
[1] Kaunas Univ Technol, Dept Organ Chem, LT-50254 Kaunas, Lithuania
[2] Lithuanian Univ Hlth Sci, Vet Acad, LT-47181 Kaunas, Lithuania
[3] Kaunas Univ Technol, Dept Food Technol, LT-50254 Kaunas, Lithuania
[4] Lithuanian Res Ctr Agr & Forestry, Rumokai Expt Stn, LT-70462 Klausuciai, Vilkaviskis Dis, Lithuania
[5] Aleksandras Stulginskis Univ, Inst Agr & Food Sci, LT-53361 Akademija, Kaunor, Lithuania
来源：
MOLECULES | 2013年 / 18卷 / 12期
关键词：
N-phenyl-N-thiocarbamoyl-beta-alanine; Hantzsch synthesis; thiazole; hydrazone; biological activity; THIOUREA COMPOUNDS; AGENTS; INHIBITORS; HARMONIZATION; CYCLIZATION; THIAZOLES; DISCOVERY; POTENT; SERIES;
D O I：
10.3390/molecules181215000
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New N,N-disubstituted beta-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-beta-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content.
引用
收藏
页码：15000 / 15018
页数：19
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