The role of adipose derived stem cells in the treatment of rotator cuff tears: from basic science to clinical application

被引：9
|
作者：
Mocini, Fabrizio [1 ]
Monteleone, Andrea Stefano [1 ]
Piazza, Piero [1 ]
Cardona, Valentina [1 ]
Vismara, Valeria [1 ]
Messinese, Piermarco [1 ]
Campana, Vincenzo [1 ]
Sircana, Giuseppe [1 ]
Maccauro, Giulio [1 ]
Saccomanno, Maristella Francesca [1 ]
机构：
[1] Fdn Policlin Univ A Gemelli, Orthopaed Inst, IRCSS, Rome, Italy
来源：
ORTHOPEDIC REVIEWS | 2020年 / 12卷
关键词：
Rotator Cuff Tears; Adipose derived stem cells; Regenerative medicine; MESENCHYMAL STROMAL CELLS; NONOPERATIVE TREATMENT; SINGLE-ROW; REPAIR; TENDON; TISSUE; OUTCOMES; SUPRASPINATUS; IMPROVEMENT; POPULATION;
D O I：
10.4081/or.2020.8682
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Over the last decade, regenerative medicine has become increasingly popular throughout the scientific community. The poor healing capacity at the tendon-bone interface makes the rotator cuff an appealing target for biologic agents. Adipose derived stem cells are mesenchymal cells with the capacity for self-renewal and multipotential differentiation. They have been recently proposed, both in isolation and as adjuvants to existing surgical therapies, for the treatment of rotator cuff tears. Several studies have been carried out in this research field, starting from the biological characteristics of adipose derived stein cells, their preparation and culture, up to the application in the experimental field on animal models and on humans. The purpose of this study was to provide a state of the art about the current basic science and clinical literature for the effectiveness of adipose derived stem cells in the treatment of rotator cuff tears.
引用
收藏
页码：100 / 104
页数：5
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