Influence of age on respiratory modulation of muscle sympathetic nerve activity, blood pressure and baroreflex function in humans

被引:21
|
作者
Shantsila, Alena [1 ]
McIntyre, David B. [1 ]
Lip, Gregory Y. H. [2 ]
Fadel, Paul J. [3 ]
Paton, Julian F. R. [4 ]
Pickering, Anthony E. [4 ]
Fisher, James P. [1 ]
机构
[1] Univ Birmingham, Coll Life & Environm Sci, Sch Sport Exercise & Rehabil Sci, Birmingham B15 2TT, W Midlands, England
[2] Univ Birmingham, Ctr Cardiovasc Sci, City Hosp, Birmingham B15 2TT, W Midlands, England
[3] Univ Missouri, Dalton Cardiovasc Res Ctr, Med Pharmacol & Physiol, Columbia, MO 65211 USA
[4] Univ Bristol, Sch Physiol & Pharmacol, Bristol CardioVasc, Bristol, Avon, England
关键词
HEART-RATE-VARIABILITY; ARTERIAL DISTENSIBILITY; OUTFLOW; HYPERTENSION; DISCHARGES; AMPLITUDE; SYSTEM; SKIN; STIMULATION; SENSITIVITY;
D O I
10.1113/EP085071
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
New Findings What is the central question of this study? Does ageing influence the respiratory-related bursting of muscle sympathetic nerve activity (MSNA) and the association between the rhythmic fluctuations in MSNA and blood pressure (Traube-Hering waves) that occur with respiration? What is the main finding and its importance? Despite the age-related elevation in MSNA, the cyclical inhibition of MSNA during respiration is similar between young and older individuals. Furthermore, central respiratory-sympathetic coupling plays a role in the generation of Traube-Hering waves in both young and older humans. Healthy ageing and alterations in respiratory-sympathetic coupling have been independently linked with heightened sympathetic neural vasoconstrictor activity. We investigated how age influences the respiratory-related modulation of muscle sympathetic nerve activity (MSNA) and the association between the rhythmic fluctuations in MSNA and blood pressure that occur with respiration (Traube-Hering waves; THW). Ten young (22 +/- 2years; mean +/- SD) and 10 older healthy men (58 +/- 6years) were studied while resting supine and breathing spontaneously. MSNA, blood pressure and respiration were recorded simultaneously. Resting values were ascertained and respiratory cycle-triggered averaging of MSNA and blood pressure measurements performed. The MSNA burst incidence was higher in older individuals [22.7 +/- 9.2 versus 42.2 +/- 13.7 bursts (100 heart beats)(-1), P<0.05], and was reduced to a similar extent in the inspiratory to postinspiratory period in young and older subjects (by approximate to 25% compared with mid- to late expiration). A similar attenuation of MSNA burst frequency (in bursts per minute), amplitude and total activity (burst frequency x mean burst amplitude) was also observed in the inspiratory to postinspiratory period in both groups. A significant positive correlation between respiratory-related MSNA and the magnitude of Traube-Hering waves was observed in all young (100%) and most older subjects (80%). These data suggest that the strength of the cyclical inhibition of MSNA during respiration is similar between young and older individuals; thus, alterations in respiratory-sympathetic coupling appear not to contribute to the age-related elevation in MSNA. Furthermore, central respiratory-sympathetic coupling plays a role in the generation of Traube-Hering waves in both healthy young and older humans.
引用
收藏
页码:1039 / 1051
页数:13
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