Synthesis of peptide aldehydes on solid support

被引：8

作者：

Paris, M

Pothion, C

Goulleux, L

Heitz, A

Martinez, J

Fehrentz, JA

机构：

[1] Univ Montpellier 1, CNRS, UMR 5810, LAPP,Fac Pharm, F-34060 Montpellier 2, France

[2] Univ Montpellier 2, CNRS, UMR 5810, LAPP,Fac Pharm, F-34060 Montpellier, France

[3] Fac Pharm Montpellier, CNRS, UMR 9955, F-34060 Montpellier 2, France

来源：

REACTIVE & FUNCTIONAL POLYMERS | 1999年 / 41卷 / 1-3期

关键词：

aldehyde; ozonolysis; phenyl ester; solid phase; Weinreb amide;

D O I：

10.1016/S1381-5148(99)00043-7

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Peptide aldehydes are of great interest as enzyme inhibitors and as starting materials for further chemistry. The solid phase synthesis of such entities is presented through three different approaches: a Weinreb amide linker, a phenyl ester linker, which both can be reduced with hydrides to yield the target molecules, and finally an unsaturated linker which produces the desired compounds by ozonolysis. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：255 / 261

页数：7

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