Gestational Trophoblastic Diseases - A Clinicopathological Study

BACKGROUND The term 'gestational trophoblastic disease', includes lesions, some of which are categorized as true neoplasms, and others that are representative of placentas that are malformed. It refers to various lesions that accompany the premalignant type, some of which are hydatidiform moles of the partial or the whole variety. The malignant type of lesions (GTD / GTN), include the following: choriocarcinoma, epithelioid trophoblastic tumour, placental site trophoblastic tumour, and invasive moles. METHODS A total number of thirty-four cases of GTD during the last two years at a tertiary care hospital was studied, relevant data was collected, and histological features studied. RESULTS 79.41% of GTDs in the present study were complete mole, 58.82% of GTDs occurred in nullipara, 52.94% cases had GTDs seen in the third decade, 14.70% cases had history of previous GTD, 5.88% cases had history of previous abortion, 2.94% cases had a history of previous ectopic pregnancy, and case with choriocarcinoma had the highest HCG levels. In contrast, case with epithelioid trophoblastic tumour had the least HCG levels. CONCLUSIONS In this particular study, it was found that most of the GTDs occurred in nulliparous women in their thirties and their occurrence increased with risk factors like a previous history of GTD, abortions, or ectopic pregnancy.