Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene

被引：13
|
作者：
Logette, E [1 ]
Solary, E [1 ]
Corcos, L [1 ]
机构：
[1] INSERM, Fac Med, U517, IFR100, F-21000 Dijon, France
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2005年 / 1738卷 / 1-3期
关键词：
human caspase-2; SREBP; lipid; transcriptional regulation; intron;
D O I：
10.1016/j.bbalip.2005.11.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sterol Regulatory Element Binding Proteins (SREBP) are transcription factors that regulate lipid synthesis. We have shown recently that the human CASP-2 gene, encoding procaspase-2, was under the positive control of SREBP-2 that transactivates several responsive elements in the promoter region. We describe here the function of an additional SREBP-responsive element located in the first intron. Remarkably, this site is uniquely responsive to SREBP-1c that is mainly involved in fatty acids synthesis. This observation, together with our recent findings, strengthens the notion that the CASP-2 gene belongs to the SREBP-responsive gene battery in human cells. (c) 2005 Elsevier B.V. All rights reserved.
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页码：1 / 5
页数：5
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