Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene

被引：13

作者：

Logette, E ^{[1
]}

Solary, E ^{[1
]}

Corcos, L ^{[1
]}

机构：

[1] INSERM, Fac Med, U517, IFR100, F-21000 Dijon, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2005年 / 1738卷 / 1-3期

关键词：

human caspase-2; SREBP; lipid; transcriptional regulation; intron;

D O I：

10.1016/j.bbalip.2005.11.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sterol Regulatory Element Binding Proteins (SREBP) are transcription factors that regulate lipid synthesis. We have shown recently that the human CASP-2 gene, encoding procaspase-2, was under the positive control of SREBP-2 that transactivates several responsive elements in the promoter region. We describe here the function of an additional SREBP-responsive element located in the first intron. Remarkably, this site is uniquely responsive to SREBP-1c that is mainly involved in fatty acids synthesis. This observation, together with our recent findings, strengthens the notion that the CASP-2 gene belongs to the SREBP-responsive gene battery in human cells. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：1 / 5

页数：5

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