Restless Legs Syndrome in Parkinson's Disease

被引：69

作者：

Peralta, Cecilia M. ^{[1
,2
]}

Frauscher, Birgit ^{[1
]}

Seppi, Klaus ^{[1
]}

Wolf, Elisabeth ^{[1
]}

Wenning, Gregor K. ^{[1
]}

Hoegl, Birgit ^{[1
]}

Poewe, Werner ^{[1
]}

机构：

[1] Innsbruck Med Univ, Dept Neurol, A-6020 Innsbruck, Austria

[2] Univ Hosp Cemic, Dept Neurol, Parkinsons Dis & Movement Disorders Clin, Buenos Aires, DF, Argentina

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 14期

关键词：

restless legs syndrome; Parkinson's disease; mimics; motor fluctuations; prevalence; PERIODIC LIMB MOVEMENTS; SLEEP; AUGMENTATION; STIMULATION; PREVALENCE; DIAGNOSIS; RISK;

D O I：

10.1002/mds.22694

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We aimed to investigate the prevalence of restless legs syndrome (RLS) according to essential diagnostic criteria, and to explore potential associations with clinical features, especially motor fluctuations, in a cohort of 113 patients with idiopathic Parkinson's disease (PD). Twenty-eight (24%) fulfilled essential diagnostic criteria for RLS. They were Younger (63.1 +/- 8.6 vs. 68.8 +/- 9.0 years; P = 0.004), had an earlier onset of PD (54.1 +/- 9.5 vs. 59.2 +/- 10.3 years; P = 0.018), and received lower levodopa equivalent doses (578.4 +/- 382.2 vs. 779.1 +/- 459.6 mg/day; P = 0.04) than patients with PD who scored negative for RLS. In 23 patients (82%), RLS symptom onset was after PD onset (mean interval, 4.5 +/- 3.7 years). The majority (n = 17 +/- 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD. (C) 2009 Movement Disorder Society

引用

页码：2076 / 2080

页数：5

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