Ruthenium half-sandwich complexes bound to protein kinase Pim-1

被引：210

作者：

Debreczeni, JÉ

Bullock, AN

Atilla, GE

Williams, DS

Bregman, H

Knapp, S ^{[1
]}

Meggers, E

机构：

[1] Univ Oxford, Ctr Struct Genom, Botnar Res Ctr, Oxford OX3 7LD, England

[2] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 10期

基金：

英国惠康基金;

关键词：

bioinorganic chemistry; inhibitors; proteins; ruthenium;

D O I：

10.1002/anie.200503468

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Keeping in shape with half a sandwich: The structure of a picomolar organoruthenium inhibitor bound to the ATP-binding site of the protein kinase Pim-1 (see picture) demonstrates that the ruthenium center has solely a structural role in organizing the organic ligands in the three-dimensional receptor space, thus yielding a structure that is complementary in shape and functional group presentation to the active site of Pim-1. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1580 / 1585

页数：6

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