Himeic Acids E-G, New 4-Pyridone Derivatives from a Culture of Aspergillus sp.

被引：5
|
作者：
Kuwana, Toshiyuki [1 ]
Miyazaki, Mitsue [1 ]
Kato, Hikaru [1 ]
Tsukamoto, Sachiko [1 ]
机构：
[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto 8620973, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 01期
关键词：
4-pyridone derivative; ubiquitin-activating enzyme (E1); fungus; UBIQUITIN-ACTIVATING ENZYME; PROTEASOME; INHIBITOR; PATHWAY; SYSTEM;
D O I：
10.1248/cpb.c12-00800
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new himeic acids E-G were isolated from a marine-derived fungus, Aspergillus sp., and their structures were determined by spectroscopic analysis. Although himeic acid A inhibited the activity of ubiquitin-activating enzyme (E1), the three new derivatives did not.
引用
收藏
页码：105 / 107
页数：3
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